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Tumor Immunology

Across
A poor screen because values can be increased in smokers
Several applications, but most applicable in monitoring
NK cells kill using this mechanism
Can evade immune defenses
A common screen. Controversial
Oncofetal antigens
Labeled antibodies detect tissue antigen
Can be elevated in ovarian cancers
Philadelphia chromosome
Some tumor cells survive
Down
100-fold higher than normal
A type of antigen found only on tumor but not on normal cells
Formation of new blood vessels
Tumors mask their surface antigens so that they are no longer accessible to the immune system
This is a mutated version of a gene that controls proliferation
Can be found on normal and tumor cells
Used to detect a chromosome translocation
Phase where usual immune system mechanisms destroy tumor cells
Chromosomal translocation is diagnostic for this
Elevated in pancreatic cancer
Confined overgrowth