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Nucleic Acid Metabolism

Across
Thymidylate synthase-requires N5, N10 -Methylene-THF which is derived from?
Activating the Ribose Sugar using PRPP is which step of De novo synthesis
What acid is Produced via Xanthine Oxidase?
Which Biosynthesis of nucleotides includes bases from our diet or nucleic acid turnover?
What compound is commonly known as Folic Acid or Vitamin B9?
What acid gets degraded down to free base & ribose sugar but can be reassembled later?
The committed step of De novo synthesis is subject to what?
In the body, Folic acid is converted to Dihydrofolate (DHF) and then to Tetrahydrofolate (THF) by which enzyme?
What is a nucleoside containing one ring called? Cytosine, Uracil, Thymine
At which site can GMP, GDP & GTP bind and Inhibit?
What is a nucleoside containing two rings called? Adenine, Guanine, Hypoxanthine
Includes a Base + Sugar
A complete lack of HGPRT causes what SEVERE Clinical Disorder?
What compounds inhibit salvage pathways?
Includes a Base + Sugar + P
Down
Which Biosynthesis of nucleotides is considered new or started from scratch?
his condition leads to an increase of organic acids which ultimately decreases kidney function and uric acid production
transferring the amine from glutamine to ribose sugar takes place in which step of De novo synthesis?
Ribonucleotide Reductase removes 2’-OH replacing it with 2’-H. This requires the use of which Enzyme to catalyze the rxn?
At which site can AMP, ADP & ATP bind and Inhibit?