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Leukemia

Across
Cells found on peripheral smear in CLL
Typically asymptomatic, pt found to have significantly elevated WBC (acute vs chronic)
Symptomatic with signs of pancytopenia: fatigue, pallor(anemia); bleeding gums, petechia (thrombocytopenia); recurrent infections, fever (low mature WBCs) (acute vs chronic)
Marker indicative of ALL
Massive splenomegaly, pancytopenia; TRAP+
How one confirms leukemia diagnosis
Mid-older age, predominantly immature myeloblasts, h/o alkylating chemo, radiation exposure
Lymphocyte predominant
Tyrosine Kinase inhibitor; Treats CML
Common presentation of AML
Pediatrics, LAD, fatigue, bleeding, bone pain
Down
PMN predominant
Elderly, B-cell neoplasm, asymptomatic
Name of new chromosome in CML (hint: Liberty bell)
Chromosomal abnormality associated with ALL
Unregulated WBC growth in bone marrow
Location of tumor burden in leukemia
Treatment for AML M3 type
Middle age, splenomegaly, asymptomatic, predominantly mature basophils/metamyelocytes