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Urea Cycle Study Tool

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Across
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Argininosuccinate is split into Fumarate and _____?
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What does Citrulline negatively modulate?
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Ornitine is a negative modulator for ___
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Periportal hepatocytes are active in
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Urea is degraded by bacteria to ____
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NH3 joins CO2 or HCO3 to form this intermediate
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CPSI + Mg2+ needs what allosteric activator to work?
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What enzyme turns argininosuccinate into fumerate and arginine?
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What enzyme joins Carbamoyl -PO4 and Ornithine?
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What type of diet must someone with a urea cycle enzyme deficient disorder follow?
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Where does this cycle occur?
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What enzyme catalyzes arginine's conversion in the last step of the cycle?
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What coenzyme is attached to argininosuccinate synthetase?
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Once citrulline is formed where in the cell does it go?
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What does high ammonia levels in the body lead to?
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Following this diet diminishes urea synthesis and significantly decreases urea nitrogen excretion.
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Arginine and ____ negatively modulate Arginino succinate
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Urea gets a C from ___
Down
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Urea is excreted in the ___
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Hepatocytes utilize ammonia for glutamine synthesis if periportal cells fail to use all the ammonia
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Diet and ______ concentrations can cause the activities of the urea cycle enzymes to fluctuate.
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______ and glucagon increase urea cycle enzymes
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Arginine gets split into ornithine and ___
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Urea gets a 2nd N from ___
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Arginino-succinate, Arginine and ___ negatively modulate Argininosuccinate synthetase + MG2+
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What is formed when Citrulline and Aspartate are joined together?
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Carbamoyl-PO4 and Ornithine form which intermediate?
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Where does the Aspartate in the urea cycle come from?
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What process of protein metabolism forms ammonia?
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Urea gets 1 N from ___
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What does this cycle remove from the body?
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How much ATP does NH3 use to form carbamoyl PO4?
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How much ATP does aspartate use to form Arginino succinate?