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Urea Cycle Study Tool

Across
Argininosuccinate is split into Fumarate and _____?
What does Citrulline negatively modulate?
Ornitine is a negative modulator for ___
Periportal hepatocytes are active in
Urea is degraded by bacteria to ____
NH3 joins CO2 or HCO3 to form this intermediate
CPSI + Mg2+ needs what allosteric activator to work?
What enzyme turns argininosuccinate into fumerate and arginine?
What enzyme joins Carbamoyl -PO4 and Ornithine?
What type of diet must someone with a urea cycle enzyme deficient disorder follow?
Where does this cycle occur?
What enzyme catalyzes arginine's conversion in the last step of the cycle?
What coenzyme is attached to argininosuccinate synthetase?
Once citrulline is formed where in the cell does it go?
What does high ammonia levels in the body lead to?
Following this diet diminishes urea synthesis and significantly decreases urea nitrogen excretion.
Arginine and ____ negatively modulate Arginino succinate
Urea gets a C from ___
Down
Urea is excreted in the ___
Hepatocytes utilize ammonia for glutamine synthesis if periportal cells fail to use all the ammonia
Diet and ______ concentrations can cause the activities of the urea cycle enzymes to fluctuate.
______ and glucagon increase urea cycle enzymes
Arginine gets split into ornithine and ___
Urea gets a 2nd N from ___
Arginino-succinate, Arginine and ___ negatively modulate Argininosuccinate synthetase + MG2+
What is formed when Citrulline and Aspartate are joined together?
Carbamoyl-PO4 and Ornithine form which intermediate?
Where does the Aspartate in the urea cycle come from?
What process of protein metabolism forms ammonia?
Urea gets 1 N from ___
What does this cycle remove from the body?
How much ATP does NH3 use to form carbamoyl PO4?
How much ATP does aspartate use to form Arginino succinate?