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Mad About Mabs

Across
Was a blackbox warning in patients taking ramucirumab
binds to Her2 near the center of the domain II dimerization arm
fully human IgG1 monoclonal antibody that inhibits the function of VEGFR-2
the formation of new blood vessels
EGFR mutations Blank as the exposure to tobacco smoke increases
Bevacizumab, a monoclonal antibody targeting blank improves PFS in gastric ca, but not OS
trastuzumab binds to domain BLANK of Her2
Hypomagnesemia and acneiform are common SEs of BLANK antagonists
Down
ramucirumab should be discontinued if urine protein level is > Blank grams/24 hr
mutation-negative (wild-type) is required to use cetuximab in metastatic colorectal cancer
this mab had its indication for Metastatic Breast cancer revoked in 2011
This study led to approval of THP in HER2positive first-line metastatic breast cancer
Trastuzumab and pertuzumab both bind to the extracellular part of HER2 but they target different Blank
Skin Toxicity and blank are the two most common SEs of cetuximab and panitumumab
Her2 and EGFR are members of what receptor family
Cetuximab plus gemcitabine failed to show a significant survival advantage in what cancer
NCCN recommends monitoring blank prior to, approximately q 3 months, and upon completion of treatment with Herceptin & Perjeta
approval of ramucirumab in the US was based on results from this trial
pro-angiogenic growth factors that plays a central role in tumor angiogenesis