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Top 200 Quiz 2

Across
BRAND. Black box warning of complex sleep behaviors
Black box warning of risk with concomitant opioid use
Sedative with dosing of 5-12.5 mg QD HS
Rapid-acting insulin; brand name Novolog
BRAND. Inhibits the SGLT2 in the proximal renal tubules of the nephron,, reducing the reabsorption of filtered glucose from the tubular lumen to lower the renal threshold for glucose, causing increase in urinary excretion of glucose & decrease plasma glucose levels
Long-acting insulin; dosed 300 units/mL; brand name Toujeo
Long-acting synthetic incretin hormone that is indicated for T2DM and chronic weight management
BRAND. sympathomimetic amine that functions similar to amphetamines, causing CNS stimulation (& NE release) and weight loss due to an anorectic effect
BRAND. Integrase inhibitor (INSTI) that inhibits the integrase enzyme from allowing viral DNA to incorporate itself into host DNA
BRAND. Promotes the release of catecholamines (primarily dopamine and norepinephrine) from their storage sites in presynaptic nerve terminals
Long-acting insulin; generic name insulin detemir
Rapid-acting insulin; generic name insulin lispro
Sulfonylurea; dosing 5-20 mg/day, IR usually broken up into BID dosing
Down
BRAND. Primarily decreases hepatic glucose production and secondarily improves peripheral insulin resistance; Common side effects are N/V/D, flatulence, abdominal discomfort
DPP-4 inhibitor dosed 5 mg QD
BRAND. Blocks the reuptake of NE and dopamine in the presynaptic neurons to stimulate the cerebral cortex; indications for ADHD and narcolepsy
BRAND. binds to benzodiazepine receptors on the postsynaptic GABA neuron to enhance the inhibitory effects of GABA and decrease neuronal excitability; generic name temazepam
Black box warning that can cause/exacerbate chronic heart failure; generic pioglitazone
Black box warning of potential abuse/dependence; brand name Concerta
Black box warning of lactic acidosis
BRAND. Black box warning of thyroid C-cell tumor risk
BRAND. INSTI + CYP3A4 inhibitor + NRTIs
DPP-4 inhibitor dosed 100 mg QD
Selective agonist for PPAR gamma that lowers blood glucose by improving target cell response/sensitivity to insulin, without increasing pancreatic insulin secretion
Binds to & closes ATP-sensitive K+ channels on pancreatic beta cells, resulting in depolarization of the cell and opening of calcium channels, increasing insulin secretion
BRAND. NRTIs that inhibit viral replication + integrase inhibitor (INSTI) that inhibits the integrase enzyme from allowing viral DNNA to incorporate intself into the host DNA