Directions: Use the Article: HBB Gene to complete the crossword puzzle below. Use a "_" for spaces between words.
COMPLETE!
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Across
Each alpha-globin and beta-globin subunit is attached to an iron-containing molecule called _____.
The abnormal version of the HBB allele that causes Sickle Cell Anemia is called ____.
The sickle-shaped cells die prematurely, which can lead to a shortage of red blood cells called _____.
HbS replaces ____ beta-globin subunits in hemoglobin
A normal HBB allele provides instructions for making a protein called ____.
HBB stands for ____.
Replacing glutamic acid causes the abnormal HbS subunits to stick together and form long, rigid molecules that bend a red blood cell into a ______.
The function of the hemoglobin found in RBCs is to deliver ____ to tissues throughout the body.
Beta-globin is a component (subunit) of a larger protein called ____.
Sickle cell anemia is caused by a particular _____ in the HBB gene
Down
Hemoglobin proteins are found inside of ____.
The HBB gene is located on chromosome ____.
In adults, hemoglobins normally consists of four protein chains: two beta-globin chains and two ______ chains.
Sickle-shaped cells are rigid and can ____ small blood vessels
The HbS mutation changes a single _____ in beta-globin.
The HBB mutation results in the production of an abnormal version of ______.
Heme contains an ____ molecule that binds to oxygen.
Changing the DNA in beta-globin results in a change in one _____ in the protein.
Glutamic acid is replaced with the amino acid _____ at position 6 in beta-globin.
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