Causes inadequate oxygen delivery related to low fluid volume of healthy RBC's, or Hgb
A type of anemia that causes bone marrow to fail to produce all three types of blood cells;
Manifestations: Fatigue, exertional dyspnea, eventually leads to tachycardia; platelet deficiency leads to bleeding problems
Uses OWN bone marrow; patient at risk for infection; critically ill
Regression of cell to an immune or undifferentiated cell type;
Associated with malignancies
Abnormal proliferation of ALL bone marrow;
Often asymptomatic in early stages; evolves to acute leukemia
Proliferation, accumulation of small, abnormal, mature lymphocytes in bone marrow;
Average Survival Rate: 7 years
Uncontrolled proliferation of myeloblasts, hyperplasia of bone marrow and spleen;
Manifestations result from neutropenia and thrombocytopenia
An anemia that is hereditary & autosomal recessive;
Deoxygenation causes RBC malformity
A type of anemia that can be caused by perforation, surgery, trauma;
Effects & manifestations depend on volume and rate of blood loss; acute or chronic
Change in normal pattern of differentiation's with cell types that are not normally found in normal area of body;
Often a result of inflammation
Down
Loss of DNA control over differentiation;
Occurs in response to adverse conditions
A type of anemia that causes premature destruction of RBC’s; Hemolysis may occur which can lead to reticulocytes
Malignant transformation of B Cells; lymphoblasts proliferate in bone marrow causing crowd growth;
Most common in: children and young adults
A type of anemia that develops when the body’s supply of iron is inadequate to optimal RBC formation
A type of therapy that damages cellular DNA; cell cannot divide and multiple
A type of therapy where cytokines modify the body’s response to cancer cells
Uses bone marrow cells from donor
A type of therapy that eradicates leukemic cells; produce remission
Induction Phase: high drug doses; damage stem cells; CSF is administered to rescue bone marrow following induction chemotherapy
Post-remission Phase: eradicate additional leukemic cells; prevent relapse
Increase in the number of normal cells;
Occurs in response to stress; increase metabolic demands; or elevated levels of hormones
A type of anemia
that is an inherited disorder of Hgb synthesis in which either alpha or beta chains are missing; children rarely reach adulthood;
Require life-long transfusions
Manifestations: splenomegaly, bronze skin
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