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T cell Time!

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Across
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IL-2 cytokine response system type
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BEST T cell activator (cell)
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T cell that expresses both CD4/CD8
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Positive Selection = ?
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T cells that cannot bind antigen-MHC complexes or react with self-antigens commit _________
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T cell binds to this to be activated along with second co-stimulatory signal
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No Notch
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Non-responsiveness & inability to proliferate due to missing co-stimulation (depressed cell)
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Number of stages of DN T cells
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Recognizes phosphorylated ITAM domains/recognizes phosphorylated adaptor molecules that recruit components of several signaling pathways
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Negative selection = _______ tolerance
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Induction of apoptosis in cells with too strong anti-self signaling
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Notch ligand (not Jagger but)
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Facilitated release by Bcl-2 proteins from the mitochondria
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T cell type activated by an APC (+ macrophages & B cells)
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Transcription factor that induces expression of many tissue-specific proteins in thymic epithelial cells
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BEST Immunology Teacher
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Cell transition stage from DN to DP
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Viral or bacterial toxin that forces binding of TCRs to MHC complexes regardless of TCR/antigen affinity
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What cytochrome C binds to during apoptosis of negative selection T cells
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Cell activation type via TH2 cells
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__________ Hypothesis involving T cell activation
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Mature T cell
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Apaf-1 oligomers bind with procaspase-9 to initiate _________
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PLCγ ________ PIP2 into secondary messengers DAG & IP3
Down
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_____ cells of thymus express notch ligands
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TCRαβ-first chain to rearrange
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Mature in the
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Activated T cell differentiation form
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Guanine Nucleotide Exchange Factor
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IL-7 signal prominent in _________ commitment of T cell development
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Early thymocytes
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CD4/CD8 helps _______ ITAM domain during the initiation of signal transduction of T cell activation
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General adhesion protein that pulls cells together creating a cluster in an immune synapse during T cell activation
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IL-4 induced TH2 subsets (TH cell differentiation)
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Two Signal Hypothesis activation signaling result
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Most distantly related Developmental T Potential
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Most important signal to tell a cell to become a T cell in Thymocyte development
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Some T cells become this during differentiation
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Activated T cells brought closer to death to reduce peripheral T cell population
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Cleavage of this initiates cell killing reactions
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(expressed) Pre-Tα chain + CD3 = ?
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Cells that first enter the thymus/express high levels of c-kit (stage)
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General adhesion protein that pulls cells together creating a cluster in an immune synapse during T cell activation
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GDP-bound state in Ras/MAPK Pathway
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"______" is a unique rearrangement of TCR/BCR genes that come from the same progenitor cell
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Rearrangement stage of TCR γ,δ,β/starts expressing CD25
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Check point stage