A protein involved in skeletal muscle contraction and that wraps around actin and prevents myosin from grabbing it. This prevents muscle contraction until the proper signal arrives.
Clinically important protein that links actin in outermost myofilalments to membrane proteins that link to endomysium. Transfers forces of muscle contraction to connective tissue ultimately leading to tendon.
Titun: huge, springy protein. Run through core of thin filament and anchor it to Z disc and M line. Help stabilize and position the thick filament. Prevent overstretching and provide recoil.
The ______________proteins tropomysoin and troponin act like a switch that determines when fiber can (and cannot) contract.
Dilated end-sacs of SR which cross the muscle fiber from one side to the other
Neither thick nor thin filaments change _________ during shortening. Only the amount of overlap changes.
Smooth ER that forms a network around each myofibril. Acts as a calcium reservoir; it releases calcium through channels to activate contraction
A T tubule and two terminal cisternae associated with it
A contractile protein made up of thick filaments and thin filaments.
Tubular infoldings of the sarcolemma which penetrate through the cell and emerge on the other side
The middle of the thick filament in which no crossbridges are present.
The precise organization of myosin and actin in cardiac and skeletal muscle cells. The A-bands(dark) and I-bands(light) alternate.
Troponin changes shape and moves ____________ off the active sites on actin.
Down
Myosin and actin do the work of contraction
Provides anchorage for thin filaments and elastic filaments. Bisects I band.
Not as dark;middle of a band: thick filaments only
A band- the darkest part is where thick filaments overlap a hexagonal array of thin filaments.
Segment between Z disc to Z disc. Functional contractile unit of muscle fiber.
Genetic defects in dystrophin produce this disabling disease
Subunits with an active site that can bind to head of myosin molecule. Presented as a free monomer called G-actin or as a part of a linear polymer microfilament, F actin.
I band- light bands. The way the bands reflect polarized light.
The two intertwined strands of actin.
_____________ activated by release of calcium into sacroplasm and its binding to troponin.
Thick filament shaped like a golf club. Two chains intertwined to form a shaft-like tail. Double globular head.
Middle of H band
Muscle cells ___________ because their individual sacromeres __________.
Small, calcium-binding protein on each tropomyosin molecule.
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