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Cytotoxic Chemotherapy Crossword #2

Across
This agent requires aggressive diarrhea management with loperamide that exceeds the OTC dosing.
This platinum based alkylating agent is has a dose limiting toxicity of nephrotoxicity in addition to hematologic toxicity.
This agent is a purine analog with a dose limiting toxicity of renal tubular damage and should not be given with fludarabine.
Leucovorin is used as rescue for high doses of this agent.
This nitrogen mustard derivative has a high incidence of nausea/vomiting and has higher incidence of secondary malignancies than other agents in the class.
Patients rarely have infusion reactions to this taxane as it ultilizes albumin-bound nanoparticles and does not require solubilizing agents.
This alkylating agent is a nitrosurea that is available as both a IV and a wafer dosage form.
This agent is an alkylating agent that binds to the minor groove of DNA and forms adducts that bend DNA towards the major groove.
This topoisomerase II inhibitor is an anthracycline with a lifetime dose limit of 900 mg/m2/lifetime.
Down
This anti-folate agent requires vitamin supplementation with folic acid and B12 and has an indication for relapsed or refractory T-cell lymphoma.
This taxane has a specific indication for the treatment of prostate cancer.
This topoisomerase I inhibitor exerts its effects primarly in S phase of the cell cycle and has both an oral and IV dosage form.
This fluoronated pyrimidine has different side effect profiles based upon whether it is administered as a continuous infusion or bolus infusion.
This topoisomerase II inhibitor is an anthracycline with a lifetime dose limit of 450-550 mg/m2/lifetime.
This alkylating agent requires the use of mesna with all doses to prevent hemorrhagic cystitis.
This agent is a cytidine analog has a preservative free solution for intrathecal administration.
This cytoprotectant can be used to treat doxorubicin extravasation.
This vinca alkaloid is typically capped at 2mg and has a dose limiting toxicity of peripheral neuropathy.
This alkylating agent needs seizure prophylaxis for high doses.
This agent is commonly associated with increased hypersensitivity reactions due to the solubilizing agent Cremophor.