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Cytotoxic Chemotherapy Crossword #1

Across
Ice chips should be avoided when patients are receiving this agent as a periorbital neuropathy can develop to exposure to cold.
This analog of adenosine, depletes T-cells and has a high risk of opportunistic infections that require prophylaxis.
This oral chemotherapy agent has a similar side effect profile to infusional fluorouracil.
This platinum based alkylating agent has a dose limiting toxicity of nephrotoxicity in addition to hematologic toxicity.
This alkylating agent is used in many cancer types and dose not typcially require mesna use with all doses, only higher doses.
This alkylating agent requires the use of mesna with all doses to prevent hemorrhagic cystitis.
This topoisomerase II inhibitor is an anthracycline with a lifetime dose limit of 900-1000 mg/m2/lifetime.
This topoisomerase II inhibitor has an oral dosage form with an IV to PO conversion of 1:2 due to only ~50% bioavailability when given orally.
Avoidance of MAOIs and tyramine in the diet are necessary when patients are taking this agent.
This agent requires aggressive diarrhea management with loperamide that exceeds the OTC dosing.
This liposomal dosage form of doxorubicin has different side effect profile than its parent drug with little to no cardiac toxicity.
This agent is commonly associated with increased hypersensitivity reactions due to the solubilizing agent Cremophor.
Down
This alkylating agent uses the Calvert equation for dosing.
This topoisomerase II inhibitor is an anthracycline with a lifetime dose limit of 150mg/m2/lifetime.
This agent is classified as a difluorinated deoxycytidine analogue which can be irritating to the vein and cause some transient flu-like symptoms.
This oral alkylating agent undergoes spontaneous hydrolysis to MTIC.
Leucovorin is used as rescue for high doses of this agent.
Severe toxicity with this agent is associated with TPMT genetic mutations.
This anti-folate agent is contraindicated in patients with CrCl <45ml/min
This agent is a taxane that has less hypersensitivity reactions since it is formulated with polysorbate 80.