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AUBAGIO Key Messages

Across
Primary end point in Teri-PRO Trial
A signal not observed in women who inadvertently became pregnant while on AUBAGIO
Efficacy was maintained of over ____ years including extension trials
This is strongly correlated with disability worsening
Main measurement used in Teri-PRO trial
Impact of high levels of treatment satisfaction
Analysis used to show all 3 oral DMTs are comparable on preventing relapses
Only oral DMT with 2 Phase III trials impacting disability worsening
Trial in early MS patients
Patients had significantly higher treatment satisfaction scores after switching to AUBAGIO from these DMTs
Down
Once-daily oral dosing can help support this
Women of childbearing potential can take AUBAGIO if they are this type of contraception
Lymphocytes and neutrophil counts were maintained within ____ ranges
No new or _____ safety signals with long-term use of AUBAGIO
Safety profile consists of up to ____ years of consistent data
Post hoc analysis of TEMSO BVL data
Real-world patient satisfaction trial
PASAT-3 was used to show that AUBAGIO improved this in TEMSO core and then maintained its effect over the extension
Changes in this was used to show the effect of AUBAGIO on early brain atrophy in the TOPIC trial