ATP binds to myosin head to _________ it from the actin.
Blocks ACh receptors. Action potential cannot be generated in the muscle and paralysis occurs.
Binding of actin to a myosin cross bridge triggers this __________.
ACh receptors on the motor end plate resulting in graded potentials.
Contain thick and thin filaments. Another name for muscle fiber.
Enzyme located in the NMJ that breaks down ACh and ends ACh activity leading to a relaxation of the muscle.
A single skeletal muscle cell. Large, elongated and cylindrical in shape that are multi-nucleated, have many mitochondria and extend the entire length of the muscle.
The chemical key to E-C coupling.
Thin muscle filament, major component.
Blocks release of ACh. Neurons cannot release enough ACh and paralysis occurs.
Autoimmune disease. ACH receptors are progressively destroyed by erroneously acting antibodies. Muscles cannot respond to ACh, causing severe muscle weakness.
Down
The "holding tank" of Ca2+ of the sarcoplasmic reticulum.
Thick muscle filament.
Chemical neurotransmitter, released by nerve cells. It controls the contraction of all skeletal or voluntary muscles.
Short-term (temporary) inhibitor of AChE, is used to treat myasthenia gravis.
Voltage sensor on the sarcoplasmic reticulum membrane on the muscle fiber.
Graded potentials that stimulate action potentials in the skeletal muscle membrane adjacent to the motor end plate.
Action potential spreads along the membrane into the _____________.
Causes explosive release of ACh, causes excess depolarization and paralysis occurs.
Striated involuntary muscle.
Un-striated involuntary muscle.
Striated voluntary muscle.
The location motor neurons and skeletal muscle fibers that are chemically linked. abbreviation
Receptor responsible for the release of Ca2+ from intracellular stores during E-C coupling. aka foot protein.
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