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Immunglobulins

Across
Forms antibody binding site
Most common isotype in serum
Immunoglobulin isotypes found on mature B cell prior to antigen stimulation
Binds to antigen-bound IgG4 and causes cell lysis
Fraction of serum where Ig is found
First isotype made by a B cell
Binding site of an antibody on an protein antigen
Occurring at a high rate in germinal centers, it alters the affinity of an antibody
Number of days of IgM half life in serum
Number of identical heavy chains in an IgG monomer
Exons in a heavy chain locus
Secreted as a pentamer
Binding of antigen bound Ig to FcR on macrophage results in?
Fragment of immunoglobulin that binds antigen
Found in breast milk
Influences the outcome of class (isotype) switch
Down
Conserved sequences of variable regions
Name of stem cell that gives rise to B cells
Crosses placenta
Polypeptide found in all Ig isotypes
Part of an immunoglobulin that give the antigen binding arms flexibility
Process which results in creation of a functional immunoglobulin gene
Human response to antibody synthesized by a mouse
Region of an immunoglobulin that defines the isotype of an antibody
Only light chain with subclasses
Worms hate this
Type of binding between an antibody and its antigen
Answer to the question, does the antigen binding site change after isotype switch?
Antibody made by one B cell
Crosslinking releases histamine
Good for agglutination
Immune response to genetic differences between humans
Immune target to the antigen binding site
Another name for immunoglobulin
Strength of binding of entire antibody - antigen complex
Highest rate of synthesis