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Immunglobulins

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Across
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Forms antibody binding site
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Most common isotype in serum
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Immunoglobulin isotypes found on mature B cell prior to antigen stimulation
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Binds to antigen-bound IgG4 and causes cell lysis
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Fraction of serum where Ig is found
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First isotype made by a B cell
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Binding site of an antibody on an protein antigen
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Occurring at a high rate in germinal centers, it alters the affinity of an antibody
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Number of days of IgM half life in serum
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Number of identical heavy chains in an IgG monomer
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Exons in a heavy chain locus
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Secreted as a pentamer
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Binding of antigen bound Ig to FcR on macrophage results in?
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Fragment of immunoglobulin that binds antigen
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Found in breast milk
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Influences the outcome of class (isotype) switch
Down
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Conserved sequences of variable regions
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Name of stem cell that gives rise to B cells
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Crosses placenta
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Polypeptide found in all Ig isotypes
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Part of an immunoglobulin that give the antigen binding arms flexibility
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Process which results in creation of a functional immunoglobulin gene
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Human response to antibody synthesized by a mouse
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Region of an immunoglobulin that defines the isotype of an antibody
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Only light chain with subclasses
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Worms hate this
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Type of binding between an antibody and its antigen
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Answer to the question, does the antigen binding site change after isotype switch?
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Antibody made by one B cell
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Crosslinking releases histamine
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Good for agglutination
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Immune response to genetic differences between humans
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Immune target to the antigen binding site
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Another name for immunoglobulin
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Strength of binding of entire antibody - antigen complex
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Highest rate of synthesis