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Neuropathology

Across
A motor neuron disease affecting the brainstem, leading to emotional instability and swallowing defects, Progressive ________ (6,5).
Most cases of Alzheimer's disease are not familial, but rather are ______ ? (8).
Affecting vision, ______ is frequently an early symptom of Multiple Sclerosis (5,8).
Parkinson's disease is characterised by a primary loss of this neurotransmitter (8).
Intra-cellular ________ tangles of the Tau protein disrupt the microtubule transport network within neurons (15).
An _______ is characterised by absence of myelin, gliosis (scarring) and decreased oligodendrocytes being present (8,8).
A motor neuron disease of upper and lower neurons is, _________ Sclerosis, with symptoms particularly visible in the arms and legs (11,7).
Multiple Sclerosis is characterised by many lesions, or _____, that generally worsen over time (8).
Multiple Sclerosis affects only neurons in the ______ Nervous System, (7).
A therapy to treat Multiple Sclerosis involves destruction of self-reactive immune cells, and replacement with hemopoietic _______ to "reset" the immune system (9).
Other than the cortex, this region of the brain is often atrophied in Alzheimer's disease, leading to significant memory loss and inability o form new memories (11).
______ motor neurons synapse onto the neuromuscular junction and directly control muscle function (5).
Because Multiple Sclerosis involves the host mounting an inflammatory response against their own proteins (antigens), MS can be classified as an ______disease (4-6).
Defects in Parkinson's disease primarily manifest in the striatum, thalamus, cortex and ________ (5,7).
Down
Parkinson's disease is characterised by cell death predominantly within the _______ (10,5).
Genetics and gender play a role in the pathogenesis of Multiple Sclerosis, thought to be linked to increased permeability of this structure (5,5,7).
A _______ is characterised by attempted repair and remyelination of neurons by oligodendrocytes (6,8).
Inter-cellular aggregates of _______ Precursor Protein (plaques) contribute to the pathogenesis of Alzheimer's disease (7).
A histological analysis of an acute inflammatory lesion in Multiple Sclerosis would likely show a "ring" of lymphocytes surrounding a blood vessel, termed perivascular ______? (7).
The inflammatory cells primarily responsible for the pathogenesis of Multiple Sclerosis (11).
The incidence of Multiple Sclerosis is highest in countries away from the equator. This correlates with an increased risk of ______, thought to be the aetiological agent in MS. (5,9).
______ motor neurons connect the brain to the appropriate "level" of neurons within the spinal cord (5).
This component of the CNS is the primary target of the self-immune response in the pathogenesis of Multiple Sclerosis (6).
An _______ is characterised by significant and ongoing inflammation and myelin destruction (6,8).
Along with macrophages, these lymphocytes are heavily involved in the pathogenesis of Multiple Sclerosis (1-5).
A ______ is an abnormal intra-cellular protein aggregate, characteristic of Parkinson's disease (4,4).