The use of this
P-glycoprotein inhibitor with dabigatran, requires you to decrease the dose of dabigatran in certain situations.
An ion that causes chelation of tetracycline and quinolone antibiotics resulting in the reduced oral
bio-availability of these antibiotics.
CYP3A4 inhibitors in particular amiodarone will reduce the metabolism of this statin, thus no more than 20mg of this statin is recommended when used with amiodarone.
This use of this particular SSRI with tamoxifen is associated with an increased mortality from breast cancer.
You can’t be a vegemite lover when you’re on this antidepressant.
Narrow therapeutic range bronchodilator that has its clearance increased by tobacco smoking. It may also lower the seizure threshold.
Hormones in oral contraceptive pills (OCP) are metabolised by CYP3A4. Taking these within 4 weeks of a CYP3A4 inducer may lead to contraception failure and hence a larger dose of the OCP is required or the use of a IUD is suggested. Which antiepileptic drug may be of issue here?
Avoid combination if possible or reduce azathioprine or 6-MP dose to one-quarter to one-third of normal and monitor complete blood count closely.
Narrow therapeutic
p-glycoprotein substrate used for rate control in atrial fibrillation and atrial flutter.
Which CYP3A4 inhibitor is used to reduce the metabolism of other protease inhibitors in order to increase the effectiveness of HIV treatment?
Medication used to reduce diarrhoea and manage hypocholesteremia. Can also interfere with the enterohepatic recycling of methotrexate resulting in decreased concentrations of methotrexate.
Down
Oral anticoagulant that interacts with many antimicrobials.
When combined with digoxin, it can lead to digoxin toxicity through the inhibition of p-glycoprotein. It is suggested to reduce the oral digoxin dose by approximately 30% to 50% when this drug is added to digoxin therapy.
Folic acid antagonist that has its renal clearance decreased when co-administered with NSAIDs and penicillins.
Antibiotic which decreases creatinine secretion in the proximal tubule, leading to increased serum concentration of creatinine without changing the true GFR.
Antibiotic used for gram negative organisms that is inactivated by the concomitant administration of penicillins and cephalosporins.
OATP1B1 is a transporting peptide located in the liver required for the hepatic uptake of most statins. Inhibition of OATP1B1 by this drug may reduce the efficacy of the statin.
A sour juice that is a known CYP3A4 (moderate) inhibitor.
Interferes with the renal tubule secretion of cephalosporins in order to increase the half-life and prolong antimicrobial activity. Ceftazidime and ceftriaxone are not affected.
Anti-emetic which its use is contraindicated with dopamine agonists.
Psychotropic agent that has its serum concentrations increased when combined with NSAIDs, thiazide diuretics, ACE inhibitors or Angiotensin 2 receptor blockers.
Antimicrobial agent used for VRE that should not concomitantly be used with SSRIs due to the increased risk of developing serotonin toxicity.
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