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To Clot or Not to Clot

Enjoy Season 2 - Episode 18 of Dr. Rhyne's Weekly Educational Snack!  Answers are attached to the email.
Across
Treatment for ITP if bleeding = steroids, Anti-D immunoglobulin, and what?
Syndrome where a vascular tumor is associated with consumptive coagulopathy, microangiopathic hemolytic anemia, and thrombocytopenia due to platelet sequestration.
Breastfed baby, born at home, presents at 1 week old or younger with bleeding. What is the deficiency?
3yo with bruising and petechiae. WBC and Hgb are normal. Platelet count of 3000. No splenomegaly on exam. Febrile viral illness 2 weeks ago. What is the most likely diagnosis? (acronym)
Antibodies are directed against phospholipid-binding proteins such as prothrombin, protein C, and protein S.
Mother wants her term newborn son circumcised. When asking about family history of bleeding, she mentions that her father (maternal GF) had severe bleeding throughout his life and died early. What should you screen for?
Platelet count less than 150,000
X-linked recessive; triad of immune deficiency (sinopulmonary infections), eczema, and low platelet count of small platelets (low MVP).
Venous thromboembolism; neonatal purpura fulminans; CNS and retinal thrombosis; rarely DIC.
Excessive bleeding with first menstrual period in an adolescent may be the first sign of this disease.
Down
AR disorder involving abnormal platelet receptor causing platelets to be unable to bind with fibrinogen and vWF.
This mutation results in mild increase in homocysteine and can cause mild risk for venous thrombosis in homozygotes. (acronym)
Bilateral absent radii, thumbs present; clino/syndactyly; petechiae and GI bleeding. (acronym)
4yo M with 3 days of fever. Exam reveals bruises, cervical LAD, palpable spleen. Labs: WBC 1200 with 18% neutrophils, Hgb 9.9, normal MCV, platelets 76,000. What is the most likely diagnosis? (acronym)
15yo F develops a DVT after being immobilized after surgery. What is the most common cause of an inherited hypercoagulable state in children?
Cofactor for protein C; deficiency of this causes similar symptoms to those of protein C deficiency
This important protein inhibits factors IX, X, XI, and XII. Without this protein, venous clots occur.