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The Gleevec Story

By Anoush Calikyan 
Acknowledgements to Dr. Edward Loechler and Patrick Stoiber
Across
A c-abl probe will selectively find human c-abl selectively through this kind of hydrogen bonding.
Bone marrow cells treated with granulocyte colony-stimulating factor and erythropoietin form these kinds of cell colonies
Gleevec renders bcr-abl inactive by binding to the
Erroneous ERK activity is usually associated with mutation in this oncogene.
Staining method used to observe chromosomes with a high affinity for DNA
The genome of retroviruses includes the genes gag, pol, and this other gene
The CML proto-oncogene
V-Abl and Bcr-abl is this kind of protein
32D cells do not grow without the addition of this growth factor
CML= Chronic _________ Leukemia
The process that occurs for much of the regulation of Abl proteins
The name for the oncogenic mouse retrovirus isolated in 1970
T3151 causes about 15% of CML patients to experience _______.
Collection of compounds with varied structure
Down
PTK inhibitor
32Dp210 cells do not need IL3 to do this
Bcr-abl-p210 protein stimulates growth, and prevents both apoptosis and THIS from occurring in CML cells
In many human cancers, the MEK/ERK signal transduction pathway is disrupted and phosphorylates too much because ERK is ________.
CML bone marrow cells treated with CGP 5718 resulted in _______ colonies
The type of mutation that causes CML
A cell that has a few of the same chromosome from a different species
CML affects these cells types of cells in humans
Gleevec
Another name for chromosome 22
Researcher who developed better staining techniques to find the longer ninth chromosome
The growth of 32Dp210 cells is_______ by CGP 57148
A type of staining that detects NDA fragmentation
The fusion gene that results from the t(9:22) translocation
RAF is upstream of this