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Obesity and Epigenetics X-Word

Across
Used to digest chromatin to study nucleosomes and non-histone proteins
Implicated in epigenetic inheritance and include subtypes like miRNAs and snoRNAs
Disorder resulting from behavioral and heritable causes
The main part of genomic DNA is wrapped around these in spermatozoa, allowing for denser packaging of DNA compared with histones
Covalent, post-translational alteration which regulate gene expression
In addition to an increased risk of obesity, children of obese men are at higher risk of developing this
Weight loss can remodel these epigenetic signatures
Showed similar profiling in the epigenome of sperm from lean and obese men
Typically occur at or near trancriptional start sites of housekeeping genes
Exercise and nutritional status induces acute changes in these patterns
Used to analyze genome-wide methylation profiles on a single nucleotide level
Down
Procedure associated with dramatic remodeling of DNA methylation, particularly in genetic locations implicated in the control of appetite
Environmentally acquired phenomenon passed on by the gametes
Bioinformatics tool used for gene ontology analysis
Play a role in genomic stability by repressing repetitive elements and regulate coding gene expression
Name of the transcript which is a regulator for food intake involved in obesity
Heritable traits that cannot be explained by DNA sequence
Procedure performed to exclude somatic cells and isolate motile spermatozoa
A potent intervention to reduce weight and resolve insulin resistance and type 2 diabetes