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Drug Action and Interactions

Across
When 2 drugs that have opposite effects are given together, each cancels the effect of the other
Length of time a drug has a pharmacologic effect
A drug becomes a solution in order to cross the biologic membrane
Lowest plasma concentration of a drug; drawn immediately before next dose is given
The time it takes for 1/2 of drug concentration to be eliminated
The time it takes to reach minimum effective concentration
Severe, unwanted drug reaction such as anaphylaxis
When 2 drugs with similar action are given, this is the sum of their effects
When 2 drugs are given together, one drug potentiates the other and clinical effect is substantially greater
When a drug passes through the liver first
Down
The process of drug movement to achieve drug action
Drug that is not bound to protein
This is affected by pain, stress, food, disease, exercise, and circulation
Main route of drug elimination
When drug level exceeds therapeutic range; may be from overdosing
Alternate effect of drug, almost expected
Drug that produces a response
Primary site of metabolism
When the drug reaches its highest blood level