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Drug Targets: How do drugs work?

Across
20 alpha amino acids that form amide bonds • Tintins: largest polypeptide • linear primary structure
•protein, peptide or nucleic acid with activity that can be modulated by a drug • drug is either small molecular weight chemical compound (SMOL) or a biologic (BIOL), such as an antibody or a recombinant protein .
Covered target classes Enzymes Receptors Transcription factors Ion Channels Transport proteins Protein-protein interface Nucleic acids
• catalysis • transport •Information
Basic unit of protein •Amino group •Carboxylic acid group •R Side chain •Hydrogen
Alpha helix Beta sheet •Folding
All macromolecules •Enzymes •G protein coupled receptor GPCR •Ion channels •Transporters
Covered target classes RNA
Down
Cysteine Methionine
Structure formed by more than one polypeptide chains • Interaction
• Not useful if it does not modify disease • not useful if it can modify disease but it cannot be successfully modulated to alter disease progression
Covered target classes: Extracellular proteins Trans-membrane receptors Cell-surface receptors Substrates and metabolites
Lysine Arginine Aspartic acid Glutamic acid Asparagine Glutamine
3-D structure formed by assembly of secondary structures •Packing
Glycine Alanine Valine Leucine Isoleucine Proline
Amino acid sequence •Assembly
Serine Threonine
Phenyalanine Tyrosine Tryptophan Histidine