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Heart Failure Topic Disucssion

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Across
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Performed when HF is suspected
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The volume of blood that is pumped by the heart in one minute
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Non-selective SGLT1&2 inhibitor, though has not been updated in the AHA guidelines
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Type of drug that can worsen HF
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Sacubitril/Valsartan (brand name)
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Only class shown to reduce mortality in HFpEF
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Inhibits reabsorption of sodium and chloride in the ascending loop of Henle and proximal and distal renal tubules
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Competes with aldosterone for receptor sites in the distal renal tubules, increasing sodium chloride and water excretion while conserving potassium
Down
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Classified by the level of limitation in physical functioning
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Occurs when the heart is unable to supply sufficient oxygen-rich blood to the body
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Measurement of how much blood is pumped out of the left ventricle
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May consider if stable chronic HF EF <35% AND in normal sinus rhythm with a resting HR of >70 BPM
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More likely to have this kind of toxicity if low potassium
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Non-inferior compared to ACE inhibitors
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Only drug studied in African Americans
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Competitive inhibitor of angiotensin-converting enzyme