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Prostate and Testicular Cancers_Urology_Khan_2023

Across
Axial skeletal involvement; metastases
Glycoprotein, benign or malignant, assess trends, elevation in serum concentration with prostate CA; recommended as first screening test
Hard, nodular, irregular, "knuckle" on DRE
"bag of worms", DDX
Prostate volume; guide prostate biopsy
Seminomas; cisplatin-based chemotherapy/ orchiectomy, and RPLND (if warranted)
Hypergonadotropic hypogonadism, 47, XXY
Increased incidence of Testicular Cancer, 4-6 fold increase
Risk with transcrotal aspiration; Should not perform
Heterogeneity, MC in oder age, rapid growing with higher incidence of metastases; not sensitive to radiation therapy
Zone with highest incidence of adenocarcinomas
Intermediate and poor risk METs; sterility
Initial diagnostic intervention; bilaterally
Testicular mass on presentation; pathognomonic
And UI; MC complication of radical prostatectomy
Down
Serum concentrations of AFP, hCG, LDH
Localized to the testis; orchiectomy and active surveillance
Non-seminomatous orchiectomy alone; high cure rate
Gold standard; radical inguinal
Perform baseline count; refer if interest in preserving fertility
PSA level to confirm elevation for diagnosis; compare with previous levels
Cancer RF: Age, AA, High-fat diet, Positive family history, obesity
MC CA in males worldwide
Localized prostate CA detection/ characterization
All patients for management of localized prostate disease or for active surveillance
Histologic scoring most commonly used for prostate CA; tumor aggressiveness
MC testicular neoplasm
MC approach in the US for biopsy
Definitive treatment of prostate cancer
Edematous and heaviness common complaints
Involvement of retroperitoneal region