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The Complement System

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Across
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Coats surface of pathogen to allow phagocytes to "grab" onto and ingest. Ex: C3b and C5b
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Release of fluid from vessels due to increased vessel permeability
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Antibody activated pathway of complement system
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Type of phagocyte. Attracted by chemotaxis. Stick to inside of vessels to escape
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Ingestion of large particles through formation of vesicles
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Creates pores on pathogen membrane to puncture holes and kill cell Ex: C5-C9
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The ultimate goal of MAC (Membrane attack complex)
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White blood cell Three types: granulocytes, lymphocytes, monocytes
Down
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Released by mast cells, cause vasodilation and increase vessel permeability
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Pathway of complement system activated by membrane attack complex (MAC)
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Make mast cells degranulate, Ex: C3a and C5a
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Chemical signals sent to attract leukocytes to site of inflammation
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Domino effect
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Proteins that produce the cascade effect in complement system
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Pathway of complement system NOT activated by antibodies
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Cell that contains a "grab bag" of chemicals (granules) that when released produce a strong immediate inflammatory response